Discussing a teacher MKT and its role on teacher practice when exploring data analysis

This article considers teacher knowledge in managing mathematically critical situations and the role of what can be termed a mathematical summary in the analysis of a teaching episode, viewed from the perspective of Mathematical Knowledge for Teaching (MKT). The analysis is based on an episode of content review, from a perspective which aims to understand the teacher’s logic rather than merely identify gaps in their knowledge. We discuss the importance of approaching mathematically critical situations in order to contribute to eradicating mathematical innumeracy (statistics) and to promote a kind of practice which is “mathematically demanding” as well as “pedagogically exciting”

Exploring Strategic Opportunities for Better Learning. Student Concerns at a Private University

This work documents the first actions that have been carried out to generate organizational strategies aimed at achieving a better learning experience among university students As a result of the confinement conditions imposed by the pandemic since 2020 it is estimated that eventually a hybrid education system will be reached where remote and face-to-face formats are combined Anticipating which are the best practices that can be developed in each modality a study was carried out among several students of a Mexican Higher Education Institution where the concerns they have about their learning experience were explored This is a mixed investigation where based on the results of a survey among a non-probabilistic population sample a strategic analysis of organizational opportunities was carried out for its application in a specific university space The discussion section offers some of the conclusions obtained as well as concrete actions that are being evaluated in pilot tests with students from a private universit

Explorando el conocimiento especializado de una maestra investigativa y su relación con la práctica

En este artículo se reportan avances de un trabajo de investigación que busca una más amplia comprensión del conocimiento matemático especializado de una maestra de primaria y las relaciones de dicho conocimiento con su práctica. Con ese objetivo, analizamos la práctica de la maestra en una clase de geometría a travésdel modelo Mathematics Teacher's Specialised Knowledge - MTSK (Carrillo et al., 2013).Los primeros resultados muestran cómo el conocimiento matemático especializado, fuertemente influenciado por la concepción que tiene la maestra sobre las matemáticas y su enseñanza y aprendizaje, influye en el desarrollo de la actividad matemática en el aula

Relaciones en la práctica entre el conocimiento matemático para la enseñanza (MKT) y las creencias del profesor

Como profesores, lo que hacemos y cómo lo hacemos se encuentra estrechamente ligado al conocimiento sobre los tópicos de enseñanza, así como al modo como encaramos todo el proceso de enseñanza. A partir del análisis de lo que sucede en un episodio de revisión en Primer Ciclo, abordamos y discutimos las relaciones intrínsecas entre las acciones llevadas a cabo, el conocimiento evidenciado (desde la perspectiva del Mathematical Knowledge for Teaching), las creencias manifestadas y su papel en el transcurso de la práctica. Las relaciones constatadas condicionan la forma como las distintas situaciones son exploradas (y las tareas preparadas) y, por tanto, las oportunidades de aprender facilitadas a los alumnos (induciendo la visión de una matemática compartimentadas y acabada)

Contra el Estado Novo y el Nuevo Estado. El movimiento estudiantil ibérico antifascista

En el presente artículo pretendemos confrontar la evolución de los movimientos estudiantiles portugueses y españoles durante sus dictaduras, centrando el análisis en las décadas de los sesenta y setenta. Se recurre a diversas fuentes primarias (entre ellas las estudiantiles) así como bibliografía científica, elaborando un ejercicio de historia comparada con la que establecemos las principales etapas y sus peculiariedades que caracterizaron la eferverscencia estudiantil de aquellos años. Todo ello encuadrado en la dinamica cultural y política internacional. A pesar de existir especificidades en cada país, se defiende que el movimiento estudiantil ibérico de estos años estuvo sometido a una cadencia reivindicativa similar, que pasó desde una fase de «autonomía estudiantil» hasta otra caracterizada por la altísima politización (cuya preocupación nuclear se encontraba fuera de la Universidad), precedida de la ruptura del movimiento unitario con la proliferación de organizaciones izquierdistas.In this article we aim to compare the evolution of the Portuguese and Spanish student movements during their dictatorships in sixties and seventies. We turn to primary sources (including those of the students) as well as specialized bibliography to elaborate a comparative history in which we establish the main phases and the peculiarities which characterized the bustle of the times within an international political and cultural context. Even though there are distinctive features within each country, we argue that the student movements of the Iberian Peninsula at that time share common features that went from an initial stage of «student autonomy» to a highly politicized phase in which the main concern lay outside the university, which was preceded by the dissolution of the unitarian movement due to the spread of extreme-left organizations in the university

Appell and Sheffer sequences: on their characterizations through functionals and examples

The aim of this paper is to present a new simple recurrence for Appell and Sheffer sequences in terms of the linear functional that defines them, and to explain how this is equivalent to several well-known characterizations appearing in the literature. We also give several examples, including integral representations of the inverse operators associated to Bernoulli and Euler polynomials, and a new integral representation of the re-scaled Hermite $d$-orthogonal polynomials generalizing the Weierstrass operator related to the Hermite polynomials

Interplay between glucose and palmitate uptake in breast carcinoma in vitro

One of the most studied tumor cells lines in vitro is the breast carcinoma MDA-MB-231 cell line. Several studies have proved its glycolytic profile, namely known as the Warburg effect. Glutamine oxidation is also important for its metabolism. Nevertheless, the use of fatty acids for obtaining energy in these cells is still rising. Palmitic acid is the most common saturated fatty acid, containing sixteen carbons in its structure. However, the use of palmitate for metabolic studies in MDA-MB-231 is not very extended due to its pro-apoptotic effect in this cell line after certain time exposure. Nonetheless, in this work we used palmitate as a metabolic fuel for just 30 minutes in order to see the almost immediate response of the cells to its presence, after a 30 minutes fast period. Our results show that MDA-MB-231 cells are not able of oxidizing palmitate nor producing lactate from it. Simultaneous presence of palmitate with glucose or with glutamine does not affect glucose nor glutamine uptake in these cells. However, we observed that even low concentrations of glucose increase palmitate uptake in MDA-MB-231 after a 30 minutes incubation. Treatment with 5 mM 2-deoxyglucose also for 30 minutes counters this rise, since 2-deoxyglucose diminishes palmitate uptake. Increasing glucose concentration to the same dosis of 2-deoxyglucose leads to a prevalence of the glucose effect on palmitate uptake. The exact role of glucose and glucose derivatives should be further studied in order to know more about palmitate metabolism in this cell line.Our experimental work is supported by grants BIO2014-56092-R (MINECO and FEDER) and P12-CTS-1507 (Andalusian Government and FEDER) and funds from group BIO-267 (Andalusian Government). The "CIBER de Enfermedades Raras" is an initiative from the ISCIII (Spain). This communication has the support of a travel grant "Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech"

Yo mismo como alguien más. La identidad personal y el lenguaje

1 archivo PDF (18 páginas). magyetnLos criterios clásicos (corporales y psicológicos) usados a través del tiempo para explicar la identidad personal no son solamente insuficientes sino poco fiables. El debate contemporáneo, notablemente el anglosajón, parece limitarse a estos dos criterios. El autor de este estudio propone un nuevo criterio de identidad personal: el criterio lingüístico. Este es a la vez un criterio ontológico (por lo constitutivo) y epistemológico (por lo cognitivo) de la identidad de la persona a través del tiempo. El autor basa sus argumentos en experiencias de la neurocirugía, apoyándose en escritos de la filosofía francesa del lenguaje. En este sentido, Paul Ricoeur, Francis Jacques y Denis Vernant son las principales referencias. ABSTRACT: The traditional criteria (physical and psychological) used over time to explain personal identity are not only insufficient but unreliable. The contemporary debate, notably the Anglo-Saxon approach, seems to be limited on these two criteria. The author of this study proposes a new criterion of personal identity: the language criterion. This one is both, an ontological (as constitutive) and epistemological approach (as cognitive) of the identity of the person across the time. The author bases his arguments on neurosurgery’s experiences, supported on writings of French philosophy of language. In this sense, Paul Ricoeur, Francis Jacques and Denis Vernant are the main references. PALABRAS CLAVE: Identidad personal, lingüística, ontológico, epistemológico, neurocirugía, personalidad, traducción e interpretación. KEYWORDS: Personal identity, linguistics, ontological, epistemological, neurosurgery, personality, translating and interpreting

Identification and characterization of new anti-angiogenic compounds from natural sources

The inhibition of angiogenesis has attracted broad attention in the field of pharmacological research, not only for cancer, but for other angiogenesis dependent diseases including ophthalmic, cutaneous and inflammatory diseases, as well as a number of rare diseases. Our research group has characterized multiple new natural bioactive compounds with multitargeted antiangiogenic effects by employing a well-established set of in vitro, in vivo and ex vivo preclinical models of angiogenesis. Most of them have been isolated from plants and terrestrial microorganisms, mainly due to their higher availability and because their therapeutic effects had been previously known in folk traditional medicines. In vitro primary screening includes cell differentiation and toxicity and proliferation assays. Secondary screening involves several experiments to evaluate effects on adhesion, migration, invasion, apoptosis or cell cycle analysis, among others. Additionally, we perform a further molecular characterization analyzing possible signaling pathways that are affected to elucidate their mechanism of action. The characterization is completed with the ex vivo aortic ring assay, and in vivo assays, as CAM and zebrafish assays, to ensure the anti-angiogenic ability. As a fruit of the mentioned screening, a number of compounds with remarkable anti-angiogenic activity have been identified and characterized.Our experimental work is supported by grants BIO2014-56092-R (MINECO and FEDER) and P12-CTS-1507 (Andalusian Government and FEDER) and funds from group BIO-267 (Andalusian Government). The "CIBER de Enfermedades Raras" is an initiative from the ISCIII (Spain)]. This communicaction has the support of a travel grant "Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech"

Fasentin, a glucose uptake inhibitor, is also able to inhibit angiogenesis

Es comunicación a congreso en formato pósterThe role of glucose on endothelial cell (EC) metabolism and angiogenesis has been an emerging issue in the last few years. Some inhibitors of glucose metabolism, such as 2-deoxyglucose, have been shown to have anti-angiogenic effects. Fasentin is a poor-studied inhibitor of glucose uptake which modulates GLUT-1 and GLUT-4 transporters in cancer cells. We wanted to test its possible effect on EC glucose uptake, showing a light decrease in HMEC at 100 µM. Lower doses did not affect this characteristic of glucose metabolism. In line with this fact, fasentin at 100 µM totally inhibited tube formation on Matrigel in these cells. This anti-angiogenic effect is not likely to be helped by a pro-apoptotic effect of fasentin but, as proved with additional assays, it could be due to a decrease on the signaling for extracellular matrix degradation. More research would be necessary in order to elucidate its fine regulation on angiogenesis and metabolism.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. [Our experimental work is supported by grants BIO2014-56092-R (MINECO and FEDER) and P12-CTS-1507 (Andalusian Government and FEDER) and funds from group BIO-267 (Andalusian Government). The "CIBER de Enfermedades Raras" is an initiative from the ISCIII (Spain). This communicaction has the support of a travel grant "Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech"]